Eukaryotic genomes are repetitively packaged into chromatin by nucleosomes, however they are regulated by the differences between nucleosomes, which establish various chromatin states.Local chromatin cues direct the inheritance and propagation of chromatin status via self-reinforcing epigenetic mechanisms.Replication-independent histone exchange co

Public concern about the environmental impact of economic activities has significantly increased around the globe in recent years.Within the scope of unlawful acts, environmental delicts are among the most serious ones in terms of environmental impact, the consequences of which directly affect the quality and development of agriculture as the main

Urothelial carcinoma (UC) comprises the majority of bladder cancers.Standard platinum-based chemotherapy has a response rate of approximately 50%, but drug resistance develops after short-term treatment.Deubiquitinating (DUB) enzyme inhibitors increase protein polyubiquitination and endoplasmic reticulum (ER) stress, which might further suppress ca

Introduction: Teratomas are neoplastic tumors derived from totipotent germ cells containing a wide assortment of tissues originating from all three germ cell layers.Teratomas can be mature or immature depending on the presence of immature tissues; typically neuroepithelial tissue.Immature teratomas can be oncologically benign or malignant, and can

Channel morphological change is often evaluated by employing sediment transport models since field data during high magnitude low frequency events is rarely available.However, sediment transport rate Porcelain Tag estimates are heuristic at best to within 1 - 3 orders of magnitude.Mimico Creek is an urban gravel-bed channel in Southern Ontario, Can